diff --git a/README.md b/README.md
index a1863af..97799a4 100644
--- a/README.md
+++ b/README.md
@@ -44,7 +44,7 @@ and WAL databases are not supported.
 - [x] file locking, compatible with SQLite on macOS/Linux/Windows
 - [ ] advanced SQLite features
   - [x] nested transactions
-  - [ ] incremental BLOB I/O
+  - [x] incremental BLOB I/O
   - [ ] online backup
   - [ ] snapshots
   - [ ] session extension
diff --git a/blob.go b/blob.go
index 739b25f..f505d69 100644
--- a/blob.go
+++ b/blob.go
@@ -1,6 +1,146 @@
 package sqlite3
 
+import "io"
+
 // ZeroBlob represents a zero-filled, length n BLOB
 // that can be used as an argument to
 // [database/sql.DB.Exec] and similar methods.
 type ZeroBlob int64
+
+// Blob is a handle to an open BLOB.
+//
+// https://www.sqlite.org/c3ref/blob.html
+type Blob struct {
+	c      *Conn
+	handle uint32
+	bytes  int64
+	offset int64
+}
+
+var _ io.ReadWriteSeeker = &Blob{}
+
+// OpenBlob opens a BLOB for incremental I/O.
+//
+// https://www.sqlite.org/c3ref/blob_open.html
+func (c *Conn) OpenBlob(db, table, column string, row uint64, write bool) (*Blob, error) {
+	defer c.arena.reset()
+	blobPtr := c.arena.new(ptrlen)
+	dbPtr := c.arena.string(db)
+	tablePtr := c.arena.string(table)
+	columnPtr := c.arena.string(column)
+
+	var flags uint64
+	if write {
+		flags = 1
+	}
+
+	r := c.call(c.api.blobOpen, uint64(c.handle),
+		uint64(dbPtr), uint64(tablePtr), uint64(columnPtr),
+		row, flags, uint64(blobPtr))
+
+	if err := c.error(r[0]); err != nil {
+		return nil, err
+	}
+
+	blob := Blob{c: c}
+	blob.handle = c.mem.readUint32(blobPtr)
+	blob.bytes = int64(c.call(c.api.blobBytes, uint64(blob.handle))[0])
+	return &blob, nil
+}
+
+// Close closes a BLOB handle.
+//
+// It is safe to close a nil, zero or closed BLOB handle.
+//
+// https://www.sqlite.org/c3ref/blob_close.html
+func (b *Blob) Close() error {
+	if b == nil || b.handle == 0 {
+		return nil
+	}
+
+	r := b.c.call(b.c.api.blobClose, uint64(b.handle))
+
+	b.handle = 0
+	return b.c.error(r[0])
+}
+
+// Size returns the size of the BLOB in bytes.
+//
+// https://www.sqlite.org/c3ref/blob_bytes.html
+func (b *Blob) Size() int64 {
+	return b.bytes
+}
+
+// Read implements the [io.Reader] interface.
+//
+// https://www.sqlite.org/c3ref/blob_read.html
+func (b *Blob) Read(p []byte) (n int, err error) {
+	if b.offset >= b.bytes {
+		return 0, io.EOF
+	}
+
+	want := int64(len(p))
+	avail := b.bytes - b.offset
+	if want > avail {
+		want = avail
+	}
+
+	ptr := b.c.new(uint64(want))
+	defer b.c.free(ptr)
+
+	r := b.c.call(b.c.api.blobRead, uint64(b.handle),
+		uint64(ptr), uint64(want), uint64(b.offset))
+	err = b.c.error(r[0])
+	if err != nil {
+		return 0, err
+	}
+
+	mem := b.c.mem.view(ptr, uint64(want))
+	copy(p, mem)
+	b.offset += want
+	if b.offset >= b.bytes {
+		err = io.EOF
+	}
+	return int(want), err
+}
+
+// Write implements the [io.Writer] interface.
+//
+// https://www.sqlite.org/c3ref/blob_write.html
+func (b *Blob) Write(p []byte) (n int, err error) {
+	offset := b.offset
+	if offset > b.bytes {
+		offset = b.bytes
+	}
+
+	ptr := b.c.newBytes(p)
+	defer b.c.free(ptr)
+
+	r := b.c.call(b.c.api.blobWrite, uint64(b.handle),
+		uint64(ptr), uint64(len(p)), uint64(offset))
+	err = b.c.error(r[0])
+	if err != nil {
+		return 0, err
+	}
+	b.offset += int64(len(p))
+	return len(p), nil
+}
+
+// Seek implements the [io.Seeker] interface.
+func (b *Blob) Seek(offset int64, whence int) (int64, error) {
+	switch whence {
+	default:
+		return 0, whenceErr
+	case io.SeekStart:
+		break
+	case io.SeekCurrent:
+		offset += b.offset
+	case io.SeekEnd:
+		offset += b.bytes
+	}
+	if offset < 0 {
+		return 0, offsetErr
+	}
+	b.offset = offset
+	return offset, nil
+}
diff --git a/error.go b/error.go
index 1c96733..d3a1cbd 100644
--- a/error.go
+++ b/error.go
@@ -203,6 +203,8 @@ const (
 	timeErr     = errorString("sqlite3: invalid time value")
 	tailErr     = errorString("sqlite3: non-empty tail")
 	notImplErr  = errorString("sqlite3: not implemented")
+	whenceErr   = errorString("sqlite3: invalid whence")
+	offsetErr   = errorString("sqlite3: invalid offset")
 )
 
 func assertErr() errorString {