diff --git a/conn.go b/conn.go
index 8ba034f..f170ccf 100644
--- a/conn.go
+++ b/conn.go
@@ -346,10 +346,9 @@ func (c *Conn) checkInterrupt() {
 }
 
 func progressCallback(ctx context.Context, mod api.Module, pDB uint32) (interrupt uint32) {
-	if c, ok := ctx.Value(connKey{}).(*Conn); ok && c.handle == pDB && c.interrupt != nil {
-		if c.interrupt.Err() != nil {
-			interrupt = 1
-		}
+	if c, ok := ctx.Value(connKey{}).(*Conn); ok && c.handle == pDB &&
+		c.interrupt != nil && c.interrupt.Err() != nil {
+		interrupt = 1
 	}
 	return interrupt
 }
@@ -363,6 +362,30 @@ func (c *Conn) BusyTimeout(timeout time.Duration) error {
 	return c.error(r)
 }
 
+func timeoutCallback(ctx context.Context, mod api.Module, pDB uint32, count, tmout int32) (retry uint32) {
+	if c, ok := ctx.Value(connKey{}).(*Conn); ok &&
+		(c.interrupt == nil || c.interrupt.Err() == nil) {
+		const delays = "\x01\x02\x05\x0a\x0f\x14\x19\x19\x19\x32\x32\x64"
+		const totals = "\x00\x01\x03\x08\x12\x21\x35\x4e\x67\x80\xb2\xe4"
+		const ndelay = int32(len(delays) - 1)
+
+		var delay, prior int32
+		if count <= ndelay {
+			delay = int32(delays[count])
+			prior = int32(totals[count])
+		} else {
+			delay = int32(delays[ndelay])
+			prior = int32(totals[ndelay]) + delay*(count-ndelay)
+		}
+
+		if delay = min(delay, tmout-prior); delay > 0 {
+			time.Sleep(time.Duration(delay) * time.Millisecond)
+			retry = 1
+		}
+	}
+	return retry
+}
+
 // BusyHandler registers a callback to handle [BUSY] errors.
 //
 // https://sqlite.org/c3ref/busy_handler.html
@@ -380,7 +403,8 @@ func (c *Conn) BusyHandler(cb func(count int) (retry bool)) error {
 }
 
 func busyCallback(ctx context.Context, mod api.Module, pDB uint32, count int32) (retry uint32) {
-	if c, ok := ctx.Value(connKey{}).(*Conn); ok && c.handle == pDB && c.busy != nil {
+	if c, ok := ctx.Value(connKey{}).(*Conn); ok && c.handle == pDB && c.busy != nil &&
+		(c.interrupt == nil || c.interrupt.Err() == nil) {
 		if c.busy(int(count)) {
 			retry = 1
 		}
diff --git a/embed/build.sh b/embed/build.sh
index 54aa170..abe5e60 100755
--- a/embed/build.sh
+++ b/embed/build.sh
@@ -8,7 +8,7 @@ BINARYEN="$ROOT/tools/binaryen-version_117/bin"
 WASI_SDK="$ROOT/tools/wasi-sdk-22.0/bin"
 
 "$WASI_SDK/clang" --target=wasm32-wasi -std=c17 -flto -g0 -O2 \
-	-Wall -Wextra -Wno-unused-parameter \
+	-Wall -Wextra -Wno-unused-parameter -Wno-unused-function \
 	-o sqlite3.wasm "$ROOT/sqlite3/main.c" \
 	-I"$ROOT/sqlite3" \
 	-mexec-model=reactor \
diff --git a/embed/sqlite3.wasm b/embed/sqlite3.wasm
index 6994d4d..519eb61 100755
Binary files a/embed/sqlite3.wasm and b/embed/sqlite3.wasm differ
diff --git a/sqlite.go b/sqlite.go
index 593ba33..61a0365 100644
--- a/sqlite.go
+++ b/sqlite.go
@@ -296,8 +296,9 @@ func (a *arena) string(s string) uint32 {
 }
 
 func exportCallbacks(env wazero.HostModuleBuilder) wazero.HostModuleBuilder {
-	util.ExportFuncIII(env, "go_busy_handler", busyCallback)
 	util.ExportFuncII(env, "go_progress_handler", progressCallback)
+	util.ExportFuncIIII(env, "go_busy_timeout", timeoutCallback)
+	util.ExportFuncIII(env, "go_busy_handler", busyCallback)
 	util.ExportFuncII(env, "go_commit_hook", commitCallback)
 	util.ExportFuncVI(env, "go_rollback_hook", rollbackCallback)
 	util.ExportFuncVIIIIJ(env, "go_update_hook", updateCallback)
diff --git a/sqlite3/busy_timeout.patch b/sqlite3/busy_timeout.patch
new file mode 100644
index 0000000..e9bbf63
--- /dev/null
+++ b/sqlite3/busy_timeout.patch
@@ -0,0 +1,13 @@
+# Replace sqliteDefaultBusyCallback.
+# This patch allows Go to handle (and interrupt) sqlite3_busy_timeout.
+--- sqlite3.c.orig
++++ sqlite3.c
+@@ -181581,7 +181581,7 @@
+   if( !sqlite3SafetyCheckOk(db) ) return SQLITE_MISUSE_BKPT;
+ #endif
+   if( ms>0 ){
+-    sqlite3_busy_handler(db, (int(*)(void*,int))sqliteDefaultBusyCallback,
++    sqlite3_busy_handler(db, (int(*)(void*,int))sqliteBusyCallback,
+                              (void*)db);
+     db->busyTimeout = ms;
+   }else{
diff --git a/sqlite3/hooks.c b/sqlite3/hooks.c
index ee9b735..c872131 100644
--- a/sqlite3/hooks.c
+++ b/sqlite3/hooks.c
@@ -4,6 +4,7 @@
 
 int go_progress_handler(void *);
 int go_busy_handler(void *, int);
+int go_busy_timeout(void *, int count, int tmout);
 
 int go_commit_hook(void *);
 void go_rollback_hook(void *);
@@ -55,4 +56,12 @@ int sqlite3_autovacuum_pages_go(sqlite3 *db, go_handle app) {
   int rc = sqlite3_autovacuum_pages(db, go_autovacuum_pages, app, go_destroy);
   if (rc) go_destroy(app);
   return rc;
-}
\ No newline at end of file
+}
+
+#ifndef sqliteBusyCallback
+
+static int sqliteBusyCallback(sqlite3 *db, int count) {
+  return go_busy_timeout(db, count, db->busyTimeout);
+}
+
+#endif
\ No newline at end of file
diff --git a/sqlite3/sqlite_cfg.h b/sqlite3/sqlite_cfg.h
index 524cc72..d86793a 100644
--- a/sqlite3/sqlite_cfg.h
+++ b/sqlite3/sqlite_cfg.h
@@ -35,8 +35,12 @@
 
 // Because Wasm does not support shared memory,
 // SQLite disables WAL for Wasm builds.
-// But we want it.
 #undef SQLITE_OMIT_WAL
 
 // Implemented in vfs.c.
-int localtime_s(struct tm *const pTm, time_t const *const pTime);
\ No newline at end of file
+int localtime_s(struct tm *const pTm, time_t const *const pTime);
+
+// Implemented in hooks.c.
+#ifndef sqliteBusyCallback
+static int sqliteBusyCallback(sqlite3 *, int);
+#endif
\ No newline at end of file
diff --git a/sqlite3/vfs_find.patch b/sqlite3/vfs_find.patch
index 8435763..861c049 100644
--- a/sqlite3/vfs_find.patch
+++ b/sqlite3/vfs_find.patch
@@ -1,7 +1,8 @@
 # Wrap sqlite3_vfs_find.
+# This patch allows Go VFSes to be (un)registered.
 --- sqlite3.c.orig
 +++ sqlite3.c
-@@ -26089,7 +26089,7 @@
+@@ -26372,7 +26372,7 @@
  ** Locate a VFS by name.  If no name is given, simply return the
  ** first VFS on the list.
  */
diff --git a/tests/txn_test.go b/tests/txn_test.go
index 415fcca..15b9809 100644
--- a/tests/txn_test.go
+++ b/tests/txn_test.go
@@ -8,6 +8,7 @@ import (
 	"github.com/ncruces/go-sqlite3"
 	_ "github.com/ncruces/go-sqlite3/embed"
 	_ "github.com/ncruces/go-sqlite3/tests/testcfg"
+	_ "github.com/ncruces/go-sqlite3/vfs/memdb"
 )
 
 func TestConn_Transaction_exec(t *testing.T) {
@@ -247,6 +248,51 @@ func TestConn_Transaction_interrupted(t *testing.T) {
 	}
 }
 
+func TestConn_Transaction_busy(t *testing.T) {
+	t.Parallel()
+
+	db1, err := sqlite3.Open("file:/test.db?vfs=memdb")
+	if err != nil {
+		t.Fatal(err)
+	}
+	defer db1.Close()
+
+	db2, err := sqlite3.Open("file:/test.db?vfs=memdb&_pragma=busy_timeout(10000)")
+	if err != nil {
+		t.Fatal(err)
+	}
+	defer db2.Close()
+
+	err = db1.Exec(`CREATE TABLE test (col)`)
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	tx, err := db1.BeginImmediate()
+	if err != nil {
+		t.Fatal(err)
+	}
+	err = db1.Exec(`INSERT INTO test VALUES (1)`)
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	ctx, cancel := context.WithCancel(context.Background())
+	db2.SetInterrupt(ctx)
+	go cancel()
+
+	_, err = db2.BeginExclusive()
+	if !errors.Is(err, sqlite3.BUSY) {
+		t.Errorf("got %v, want sqlite3.BUSY", err)
+	}
+
+	err = nil
+	tx.End(&err)
+	if err != nil {
+		t.Fatal(err)
+	}
+}
+
 func TestConn_Transaction_rollback(t *testing.T) {
 	t.Parallel()
 
diff --git a/vfs/tests/mptest/testdata/main.c b/vfs/tests/mptest/testdata/main.c
index 4e9688e..ba02c75 100644
--- a/vfs/tests/mptest/testdata/main.c
+++ b/vfs/tests/mptest/testdata/main.c
@@ -1,5 +1,7 @@
 #include <unistd.h>
 
+#define sqliteBusyCallback sqliteDefaultBusyCallback
+
 // Amalgamation
 #include "sqlite3.c"
 // VFS
diff --git a/vfs/tests/speedtest1/testdata/main.c b/vfs/tests/speedtest1/testdata/main.c
index a203a3b..a5d6a5e 100644
--- a/vfs/tests/speedtest1/testdata/main.c
+++ b/vfs/tests/speedtest1/testdata/main.c
@@ -1,6 +1,8 @@
 #include <stdbool.h>
 #include <stddef.h>
 
+#define sqliteBusyCallback sqliteDefaultBusyCallback
+
 // Amalgamation
 #include "sqlite3.c"
 // VFS